1. Selected Publications
a. Book Chapters
Xiong, Z. and Li, S., “The transformation of research results of bio-manufacturing engineering to undergraduate teaching resources”, in “The case collection of transforming scientific research achievements into teaching resources of Tsinghua University”, 2007, Tsinghua University Press, ISBN: 9787302156529.
b. Journal articles:
1. Mo, X., Zhang, Y., Wang, Z., Zhou, X., Zhang, Z., Fang, Y., Fan, Z., Guo, Y., Zhang, T., Xiong, Z. Satellite-Based On-Orbit Printing of 3D Tumor Models. Advanced Materials, 2023, 202309618
2. Liu, Y., Li, X., Pei, B., Ge, L., Xiong, Z., Zhang, Z. Towards smart scanning probe lithography: a framework accelerating nano-fabrication process with in-situ characterization via machine learning. Microsystems and Nanoengineering. 2023, 9(1), 128
3. Fang, Y., Ji, M., Wu, B., Xu, X., Wang, G., Zhang, Y., Xia, Y., Li, Z., Zhang, T., Sun, W., Xiong, Z. Engineering Highly Vascularized Bone Tissues by 3D Bioprinting of Granular Prevascularized Spheroids. ACS Applied Materials and Interfaces. 2023, 15(37): 43492–43502
4. Fang, Y., Ji, M., Yang, Y., Guo, Y., Sun, R., Zhang, T., Sun, W., Xiong, Z. 3D printing of vascularized hepatic tissues with a high cell density and heterogeneous microenvironment. Biofabrication. 2023, 15, 045004
5. Ye, M., Shan, Y., Lu, B., Luo, H., Li, B., Zhang, Y., Wang, Z., Guo, Y., Ouyang, L., Gu, J., Xiong, Z., Zhang, T. Creating a semi-opened micro-cavity ovary through sacrificial microspheres as an in vitro model for discovering the potential effect of ovarian toxic agents. Bioactive Materials, 2023, 26: 216–230
6. Fang, Y., Guo, Y., Wu, B., Liu, Z., Ye, M., Xu, Y., Ji, M., Chen, L., Lu, B., Nie, K., Wang, Z., Luo, J., Zhang, T., Sun, W., Xiong, Z. Expanding Embedded 3D Bioprinting Capability for Engineering Complex Organs with Freeform Vascular Networks. Advanced Materials, 2023, 35(22), 2205082
7. Fang, Y., Wang, C., Liu, Z., Ko, J., Chen, L., Zhang, T., Xiong, Z., Zhang, L., Sun, W. 3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration. Advanced Science, 2023, 10(12), 2205744
8. Lu, B., Ye, M., Xia, J., Zhang, Z., Xiong, Z., Zhang, T. Electrical Stimulation Promotes the Vascularization and Functionalization of an Engineered Biomimetic Human Cardiac Tissue. Advanced Healthcare Materials. 2023, 2300607
9. Xia, J., Xiong, Z., Guo, J., Wang, Y., Luo, Y., Sun, Y., Guo, Z., Lu, B., Zhang, T., Sun, W. Study of paraquat-induced pulmonary fibrosis using biomimetic micro-lung chips. Biofabrication. 2023, 15: 104104
10. Zhang, Y., Wang, Z., Hu, Q., Luo, H., Lu, B., Gao, Y., Qiao, Z., Zhou, Y., Fang, Y., Gu, J., Zhang, T. and Xiong, Z. 3D Bioprinted GelMA-Nanoclay Hydrogels Induce Colorectal Cancer Stem Cells Through Activating Wnt/β-Catenin Signaling. Small. 2022, 18(18): 2200364
11. Ji, J., Wang, C., Xiong, Z., Pang, Y. and Sun, W. 3D-printed scaffold with halloysite nanotubes laden as a sequential drug delivery system regulates vascularized bone tissue healing. Materials Today Advances. 2022, 15: 100259
12. Mo, X., Ouyang, L., Xiong, Z., Zhang, T. Advances in digital light processing of hydrogels. Biomedical Materials (Bristol). 2022, 17(4) 042002
13. Fang, Y., Sun, W., Zhang, T. and Xiong, Z. Recent advances on bioengineering approaches for fabrication of functional engineered cardiac pumps: A review. Biomaterials. 2022, 280: 121298
14. Fang, Y., Guo Y., Liu, T., Xu, R., Mao, S., Mo, X., Zhang, T., Ouyang, L., Xiong, Z., Sun, W. Advances in 3D Bioprinting. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers. 2022, 1(1): 100011.
15. Xu, Y., Wang, C., Yang, Y., Liu, H., Xiong, Z., Zhang, T., Sun, W. A Multifunctional 3D Bioprinting System for Construction of Complex Tissue Structure Scaffolds: Design and Application. International Journal of Bioprinting. 2022, 8(4): 617
16. Liu, T., Zhou, C., Shao, Y., Xiong, Z., Weng, D., Pang, Y., Sun, W. Construction and Application of in vitro Alveolar Models Based on 3D Printing Technology. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers. 2022, 1(1):100025
17. Ye, M., Lu, B., Zhang, X., Li, B., Xiong, Z., Zhang, T. Coaxial Embedded Printing of Gelatin Methacryloyl–alginate Double Network Hydrogel for Multilayer Vascular Tubes. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers. 2022, 1(1):100024
18. Fang, Y., Guo, Y., Ji, M., Li, B., Guo, Y., Zhu, J., Zhang, T., and Xiong, Z. 3D Printing of Cell-laden Microgel-based Biphasic Bioink with Heterogeneous Microenvironment for Biomedical Applications. Advanced Funtional Materials. 2021,31(51):2109810
19. Lu, B., Li M., Fang, Y., Liu, Z., Zhang, T., and Xiong, Z. Rapid fabrication of cell-laden microfibers for construction of aligned biomimetic tissue. Frontiers in Bioengineering and Biotechnology. 2021, 8: 610249
20. Li, ZY., Jia, SJ., Xiong, Z., Long, QF., Yan, SR., Hao, F., Liu, J., Yuan, Z. 3D-printed scaffolds with calcified layer for osteochondral tissue engineering. Journal of Bioscience and Bioengineering, 2018, 126(3): 389-396.
21. Jia, S. &, Wang, J., Zhang, T., Pan, W., Li, Z., He, X., Yang, C., Wu, Q., Sun, W., Xiong, Z., Hao, D. Multilayered Scaffold with a Compact Interfacial Layer Enhances Osteochondral Defect Repair. ACS Applied Materials and Interfaces, 2018, 10, 20296–20305.
22. Zhang, T., Zhang, H., Zhang, L., Jia, S., Liu, J., Xiong, Z., & Sun, W. Biomimetic design and fabrication of multilayered osteochondral scaffolds by low-temperature deposition manufacturing and thermal-induced phase-separation techniques, Biofabrication, 2017, 9(2).
23. Jia, S.&, Zhang, T., Xiong, Z., Pan, W., Liu, J., and Sun, W. In vivo evaluation of a novel oriented scaffold-BMSC construct for enhancing full-thickness articular cartilage repair in a rabbit model. PLoS ONE, 2015, 10.
24. Zhang, T., Jin, L., Fang, Y., Lin, F., Sun, W., and Xiong, Z. Fabrication of biomimetic scaffolds with oriented porous morphology for cardiac tissue engineering. Journal of Biomaterials and Tissue Engineering,2014, 4, 1030–1039.
25. Da, H.&, Jia, S.J.&, Meng, G.L., Cheng, J.H., Zhou, W., Xiong, Z., Mu, Y.J., and Liu, J. The Impact of Compact Layer in Biphasic Scaffold on Osteochondral Tissue Engineering. PLoS ONE, 2013, 8(1)
26. Zhang, T.&, Wan, L.Q., Xiong, Z., Marsano, A., Maidhof, R., Park, M., Yan, Y., and Vunjak-Novakovic, G. Channelled scaffolds for engineering myocardium with mechanical stimulation. Journal of Tissue Engineering and Regenerative Medicine 2012, 6, 748–756.
27. Wang, C., Meng, G., Zhang, L., Xiong, Z., and Liu, J. Physical properties and biocompatibility of a core-sheath structure composite scaffold for bone tissue engineering in vitro. Journal of Biomedicine and Biotechnology, 2012.
28. Jia, S.&, Liu, L., Pan, W., Meng, G., Duan, C., Zhang, L., Xiong, Z., and Liu, J. Oriented cartilage extracellular matrix-derived scaffold for cartilage tissue engineering. Journal of Bioscience and Bioengineering, 2012, 113, 647–653.
29. Xia, Y., Mei, F., Duan, Y., Gao, Y., Xiong, Z., Zhang, T., and Zhang, H. Bone tissue engineering using bone marrow stromal cells and an injectable sodium alginate/gelatin scaffold. Journal of Biomedical Materials Research - Part A, 2012, 100 A, 1044–1050.
30. Hao, W., Pang, L., Jiang, M., Lv, R., Xiong, Z., and Hu, Y.Y. Skeletal repair in rabbits using a novel biomimetic composite based on adipose-derived stem cells encapsulated in collagen I gel with PLGA-β-TCP Scaffold. Journal of Orthopaedic Research, 2010, 28, 252–257.
31. Makitie, A.A., Yan, Y., Wang, X., Xiong, Z., Paloheimo, K.S., Tuomi, J., Paloheimo, M., Salo, J., and Renkonen, R. In vitro evaluation of a 3D PLGA-TCP composite scaffold in an experimental bioreactor. Journal of Bioactive and Compatible Polymers, 2009, 24, 75–83.
32. Liu, L., Xiong, Z., Yan, Y., Zhang, R., Wang, X., and Jin, L. Multinozzle low-temperature deposition system for construction of gradient tissue engineering scaffolds. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2009, 88, 254–263
33. Ma, X., Wu, X., Wu, Y., Liu, J., Xiong, Z., Lv, R., Yan, Y., Wang, J., and Li, D. Posterolateral spinal fusion in rabbits using a RP-based PLGA/ TCP/Col/BMSCs-OB biomimetic grafting material. Journal of Bioactive and Compatible Polymers, 2009, 24, 457–472.
34. Ma, X., Wu, X., Hu, Y., Xiong, Z., Lv, R., Wang, J., Li, D., and Yan, Y. Intervertebral spinal fusion using a RP-based PLGA/TCP/ bBMP biomimetic grafting material. Journal of Bioactive and Compatible Polymers, 2009, 24, 146–157.
35. Li, S.&, Yan, Y., Xiong, Z., Weng, C., Zhang, R., and Wang, X. Gradient hydrogel construct based on an improved cell assembling system. Journal of Bioactive and Compatible Polymers,2009, 24, 84–99.
36. Li, S., Xiong, Z., Wang, X., Yan, Y., Liu, H., and Zhang, R. Direct fabrication of a hybrid cell/hydrogel construct by a double-nozzle assembling technology. Journal of Bioactive and Compatible Polymers, 2009, 24(3), 249–265.
37. Liu, L.&, Xiong, Z., Zhang, R., Jin, L., and Yan, Y. A novel osteochondral scaffold fabricated via multi-nozzle low-temperature deposition manufacturing. Journal of Bioactive and Compatible Polymers, 2009, 24, 18–30.
38. Yu, D., Li, Q., Mu, X., Chang, T., and Xiong, Z. Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology. International Journal of Oral and Maxillofacial Surgery, 2008, 37, 929–934.
39. Hao, W., Hu, Y.Y., Wei, Y.Y., Pang, L., Lv, R., Bai, J.P., Xiong, Z., and Jiang, M. Collagen I gel can facilitate homogenous bone formation of adipose-derived stem cells in PLGA-β-TCP scaffold. Cells Tissues Organs, 2008, 187, 89–102.
40. Cheng, J., Lin, F., Liu, H., Yan, Y., Wang, X., Zhang, R., and Xiong, Z. Rheological properties of cell-hydrogel composites extruding through small-diameter tips. Journal of Manufacturing Science and Engineering, Transactions of the ASME, 2008, 130, 0210141–0210145.
41. Liu, L., Xiong, Z., Yan, Y., Hu, Y., Zhang, R., and Wang, S. Porous morphology, porosity, mechanical properties of poly(α-hydroxy acid)-tricalcium phosphate composite scaffolds fabricated by low-temperature deposition. Journal of Biomedical Materials Research - Part A, 2007, 82, 618–629.
42. Zhang, T., Yan, Y., Wang, X., Xiong, Z., Lin, F., Wu, R., and Zhang, R. Three-dimensional gelatin and gelatin/hyaluronan hydrogel structures for traumatic brain injury. Journal of Bioactive and Compatible Polymers, 2007, 22, 19–29.
43. Pang, L., Hu, Y., Yan, Y., Liu, L., Xiong, Z., Wei, Y., and Bai, J. Surface modification of PLGA/β-TCP scaffold for bone tissue engineering: Hybridization with collagen and apatite. Surface and Coatings Technology, 2007 201, 9549–9557.
44. Xu, W., Wang, XH., Yan, YN., Zheng, W., Xiong, Z., Lin, F., Wu, RD., Zhang, RJ. Rapid prototyping three-dimensional cell/gelatin/fibrinogen constructs for medical regeneration. Journal of Bioactive and Compatible Polymers. 2007, 22(4):363-377
45. Yang, F., Cui, W., Xiong, Z., Liu, L., Bei, J., and Wang, S. Poly(l,l-lactide-co-glycolide)/tricalcium phosphate composite scaffold and its various changes during degradation in vitro. Polymer Degradation and Stability, 2006, 91, 3065–307.
46. Wang, X., Yan, Y., Pan, Y., Xiong, Z., Liu, H., Cheng, J., Liu, F., Lin, F., Wu, R., Zhang, R., Lu, Q. Generation of three-dimensional hepatocyte/gelatin structures with rapid prototyping system. Tissue Engineering, 2006, 12, 83–90.
47. Yu, X., Bichtelen, A., Wang, X., Yan, Y., Lin, F., Xiong, Z., Wu, R., Zhang, R., and Lu, Q. Collagen/chitosan/heparin complex with improved biocompatibility for hepatic tissue engineering. Journal of Bioactive and Compatible Polymers, 2005, 20, 15–28.
48. Yan, Y., Wang, X., Pan, Y., Liu, H., Cheng, J., Xiong, Z., Lin, F., Wu, R., Zhang, R., and Lu, Q. Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique. Biomaterials, 2005, 26, 5864–5871.
49. Wang, X., Liang, X., Xiong, Z., Yan, Y., Zhang, R., Lin, F., Wu, RD., Lu, Q., Fan, Y. A dissolvable intralumental stent for sutureless vascular anastomosis. ASBM6: Advanced Biomaterials VI Series: Key Engineering Materials. 2005, 288-289:575-578
50. Wang, X., Yan, Y., Xiong, Z., Lin, F., Wu, R., Zhang, R., and Lu, Q. Preparation and evaluation of ammonia-treated collagen/chitosan matrices for liver tissue engineering. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2005, 75, 91–98.
51. Wang, X., Yan, Y., Lin, F., Xiong, Z., Wu, R., Zhang, R., and Lu, Q. Preparation and characterization of a collagen/chitosan/heparin matrix for an implantable bioartificial liver. Journal of Biomaterials Science, Polymer Edition, 2005, 16, 1063–1080.
52. Yan, Y., Wang, X., Xiong, Z., Liu, H., Liu, F., Lin, F., Wu, R., Zhang, R., Lu, Q. Direct construction of a three-dimensional structure with cells and hydrogel. Journal of Bioactive and Compatible polymers. 2005, 20(3) 259-269
53. Xiong, Z., Yan, Y., Zhang, R., Wang, X., Organism manufacturing engineering based on rapid prototyping principles. Rapid Prototyping Journal. 2005,11(3)
54. Yan, Y., Wu, R., Zhang, R., Xiong, Z., and Lin, F. Biomaterial forming research using RP technology. Rapid Prototyping Journal, 2003, 9, 142–149.
55. Hu, Y., Zhang, C., Zhang, S., Xiong, Z., and Xu, J. Development of a porous poly(L-lactic acid)/ hydroxyapatite/collagen scaffold as a BMP delivery system and its use in healing canine segmental bone defect. Journal of Biomedical Materials Research - Part A,2003, 67, 591–598.
56. Yan, Y., Xiong, Z., Hu, Y., Wang, S., Zhang, R., and Zhang, C. Layered manufacturing of tissue engineering scaffolds via multi-nozzle deposition. Materials Letters,2003, 57(18), 2623–2628.
57. Xiong, Z., Yan, Y., Wang, S., Zhang, R., and Zhang, C. Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition. Scripta Materialia ,2002, 46, 771–776.
58. Xiong, Z., Yan, Y., Zhang, R., and Sun, L. Fabrication of porous poly(L-lactic acid) scaffolds for bone tissue engineering via precise extrusion. Scripta Materialia, 2001, 45, 773–779.
2. Funded research proposals (Selected)
1. “Engineering functional myocardial chambers by in situ induction of pluripotent stem cells and sequential 3D suspension printing strategy”, National Nature Science Foundation of China, RMB2,600,000 (01/2022 - 12/2025), as PI
2. “Research on the construction and application of tissue engineered osteochondral scaffolds with biomimetic structure”, National Nature Science Foundation of China, RMB330,000 (01/2011 - 12/2013), as PI
3. “Research on hydrogel rapid prototyping based on biomimetic process”, National Nature Science Foundation of China, RMB280,000 (01/2006 - 12/2008), as PI
4. “Research on cell and cell / material micro-drop assembly forming and its basic biology”, National Nature Science Foundation of China, RMB80,000 (01/2004 - /12/2004), as PI
5. “Basic research on 3D controlled assembly of cell / material droplets”, Major sub-projects of Beijing science and technology plan, RMB150,000 (10/2003 – 10/2006), as PI
6. “Rapid prototyping and basic research on personalized repair of goat skull defect”, National Nature Science Foundation of China, RMB180,000 (01/2005 – 10/2007), as Co-PI
3. Authorized Patents (Selected)
“A construction method and device of personalized tumor assembloids based on droplet microfluidics technology”. Inventors: Xiong, Z., Zhang, Y., Zhang T., Luo, H. Patent No. 2021106139836, July 7, 2023
“A sequential embedded printing method for constructing complex heterogeneous tissues and organs”. Inventors: Xiong, Z., Fang, Y., Zhang, T., Guo, Y., Guo, Y. Patent No. 2021105262513, Oct 21, 2022
“An artificial ventricle with biomimetic spiral oriented microstructure and its preparation method”，Inventors: Xiong, Z., Fang, Y., Zhang, T., Lu. B. Patent No.: 2021105988101, May 3, 2022
4. “A remote control automatic 3D Bioprinting system based on Microsatellite”，Inventors: Xiong, Z., Zhang, T., Mo, X., Lu, B., Zhang, Y. Patent No.: 2020109838128, April 1, 2022
“A kind of tissue engineered bone/cartilage composite scaffold and its preparation method”, Inventors: Xiong, Z., Zhang, T., Liu, J., Meng, G., Zhang, L., Lin, F., Sun, W., Li, D. Patent No.: 2012103449085, May 20, 2015
“A kind of tissue engineered fiber bundle construct and its preparation method”, Inventors: Xiong, Z., Li, M., Zhang, T., Sun, W., Zhang, R., Lin, F. Patent No.: 2011103211655, April 9, 2014
“A bioreactor for tissue engineered myocardial constructs by pour, perfusion and pulsation culture”, Inventors: Xiong, Z., Hu, J., Zhang, T., Zhang, R., Lin, F., Yan, Y. Patent No.: 201010133838X, May 2, 2012
“A kind of hydrogel rapid prototyping process based on bionic process”, Inventors: Xiong, Z., Yan, Y., Li, S., Wang, X., Wu, R., Lin, F., Zhang, R., Lu, Q., Liu, H. Patent No.: 2006100115509, July 23, 2008
“A three-dimensional controlled assembling method of cell material unit”, Inventors: Yan, Y., Xiong, Z., Wang, X., Lin, F., Wu, R., Zhang, R., Lu, Q. Patent No.: 2004100097874, August 2, 2006
