具有生物工程、药学、化学等多学科交叉领域学习及科研工作背景,研究兴趣及目标集中在生物制造、生物三维打印领域的新方法、新技术及新应用探索,旨在通过新型工程技术手段实现功能性器官组织微单元的体外仿生构建,并进一步展开其作为组织修复物、药物缓释体系、药物筛选及评价模型、病理及炎症模型的应用研究。代表性研究工作包括大型化移植用人工肝、载药缓释型宫颈修复体、血管化肺泡/胰腺、个性化体外肿瘤模型、3D打印微生物电极。
主持国家级、省部级课题2项和横向课题2项,参与国家自然科学重点基金、国家863、新药创制重大专项、中国科学院战略性先导科技专项等国家级和省部级项目5项。以通讯和第一作者发表高水平SCI及国际学术会议论文40余篇,研究工作被日刊工业新闻多次采访报道。10余次在国内外相关领域重要学术会议中宣读报告。为领域五部高水平期刊Arterioscl Throm Vas、Biotech&Bioeng、Biomater Sci、J Mater Sci-Mater M、Hepatol Int担任审稿人。
目前开展中的研究包括:
1. 载药缓释型功能性软组织的体外3D打印构建研究;
2. 多细胞异质肿瘤模型的3D打印构建及其病理学研究;
3. 血管化类器官的体外构建研究及体外/体内应用;
4. 3D打印梯度多孔三维电极用于构建微生物电化学系统
负责及参与主要科研项目
1. 日本文部省短期访问项目,Construction of implantable pancreatic tissue based on 3D design, fabrication and culture of hollowed micro-scaffold,2019,在研,主持;
2. 国家自然科学基金委青年基金项目,51805294,载药缓释型仿生软组织替代物的拓扑结构设计及3D打印重构,2019/01/01-2021/12/31,在研,主持;
3. 北京市自然科学基金青年项目,3184049,基于3D打印技术的个性化宫颈仿生重构体构建及其蛋白缓释模型研究,2018/01/01-2019/12/31,在研,主持;
4. 上普博源(北京)生物科技有限公司技术服务,3D打印个性化医疗器械模型构建研究,2018/08/01-2020/8/15,在研,主持;
5. 重庆大学技术开发,20182000840,3D打印梯度多孔三维电极,2018/5/1-2018/9/30,在研,主持;
6. 中国科学院“空间科学(二期)”战略性先导科技专项“空间科学预先研究项目”(第一批),XDA15014300,空间微生理系统的3D打印构建及应用,2018/01-2019/12,在研,骨干参加;
7. 山西转型综合改革示范区科技创新项目,医学3D打印在宫颈锥切术术后宫颈缺损修复中的应用,2018/08-2021/08,在研,骨干参加;
8. 清华大学摩擦学国家重点实验室自主研究课题,SKLT2018C06,氟磷灰石微晶玻璃表面细菌黏附机理及抗黏附技术研究,2018/01-2019/12,在研,骨干参加;
9. 新加坡国立大学技术开发,EBM和SLM技术对医学植入物的特征和比较,2018/12-2019/12,在研,参加;
10. 国家自然科学基金委重点项目,51235006,基于细胞精确受控组装体外仿生模型构建的基础研究,2013/01-2017/12,已结题,骨干参加;
11. 山西锦波生物医药股份有限公司技术开发,041502644,3D打印宫颈仿生构建技术研发及应用,2015/10/01-2017/09/30,已结题,骨干参加,
12. 东京大学生产技术研究所博士后基金项目,Microfabrication of new tissue building units having hollow structures and their feasibility in liver tissue engineering,2013/10-2015/03,已结题,主持;
13. 日本文部科学省基盘研究A,22246101,埋込み型膵島・肝組織の設計・生体外構築育成のための方法論の確立と実証(植入式胰岛•肝组织的设计、体外培养方法的建立与示范),2010/04-2014/03,已结题,参加;
14. 东京大学Global COE program-Center for Medical System Innovation,A three-dimensional scaffold with endothelialized microvascularture for in vitro liver tissue engineering,2010/10-2013/03,已结题,主持;
15. 国家自然科学基金青年项目,20805060,新型吖啶酯类化学发光试剂的合成及其在肿瘤相关酶活性测定的研究,2009/01-2011/12,30万元,已结题,参加;
16. 国家自然科学基金面上项目,20775096,高电场作用对微乳类毛细管电泳性质影响研究,2008/01-2010/12,28万元,已结题,参加。
主要期刊论文
[1]. Y. Pang, SS. Mao, R. Yao, JY. He, ZZ. Zhou, L. Feng, KT. Zhang, SJ. Cheng and W. Sun*. TGF-β induced Epithelial-mesenchymal Transition in advanced cervical tumor model by 3D printing. Biofabrication, 10 (2018) 044102;获得Physicsworld新闻在线采访报道;
[2]. Y. Pang, F. Yang, Q. Gou, Z. Xia*. Rapid evaluation of antioxidants using a self-assembled capillary electrophoresis-chemiluminescence system. Basic & Clinical Pharmacology & Toxicology, 2017, 121 (Suppl. 5), 38-39.
[3]. Y. Pang, F. Yang, Q. Gou, Z. Xia*. Screening and evaluation of plasma protein binding effects to antioxidants in Herbal Ephedrae by capillary electrophoresis with chemiluminescence detection Basic & Clinical Pharmacology & Toxicology, 2016, 119 (Suppl. 2), 35.
[4]. Y. Pang*, Y. Horimoto, S. Sutoko, K. Montagne, M. Shinohara, D. Mathiue, K. Komori, M. Anzai, T. Niino, Y. Sakai. Novel integrative methodology for engineering large liver tissue equivalents based on three-dimensional scaffold fabrication and cellular aggregate assembly. Biofabrication, 8 (2016) 035016.
[5]. Y. Pang, Y. Huang, F. Li, F. Yang, Z. Xia*. Rapid screening and evaluation of antioxidants in alkaloidal natural products by capillary electrophoresis with chemiluminescence detection. Analytical Methods, 2016, 8, 6545 - 6553.
[6]. Y. Pang*, S. Sutoko, Y. Horimoto, M. Anzai, T. Niino, Y. Sakai. Microfabrication and perfusion culture of new tissue Elements Possessing Hollow Structures with High Mechanical Strength towards Scaling-up to Implantable Liver. Tissue Engineering Part A, 2015, 21(S1), S3-S4.
[7]. Y. Pang*, S. Sutoko, Y. Horimoto, M. Anzai, T. Niino, Y. Sakai. An insight into in vitro construction of implantable liver: from “bottom up” integrated with “top down” aspects. Seisan Kenkyu, 2015, 67(3), 259-264.
[8]. Y. Pang*, K. Montagne, M. Shinohara, K. Komori, Y. Sakai. Liver tissue engineering based on aggregate assembly: efficient formation of endothelialized rat hepatocyte aggregates and their immobilization with biodegradable fibers. Biofabrication, 2012, 4(4), 045004. (封面亮点文章)
[9]. T. Moro, Y. Itagaki, Y. Pang, I Horiguchi, Y. Sakai, T. Niino. Evaluation of scaffolds with plastic laser sintering of mixture of alkali-soluble filler. Seisan Kenkyu, 2015, 67(6), 617-623.
[10].Y. Sakai*, Y. Pang, Y. Horimoto, M. Anzai, T. Niino. Tissue engineering scaffolds consisting of a macro-scale 3D flow channel network and small chambers. Bioindustry, 2014, 31(1), 45-50.
[11].Y. Sakai*, Y. Pang, Y. Horimoto, M. Anzai, T. Niino. Design and organization of liver tissues based on oxygen supply. Journal of the heat transfer society of Japan, 2014, 53(222), 10-5.
[12].Z. Xia*, Y. Pang, G. Zheng. Study on the Antioxidantive Biological Fingerprints of Astragalus Based on Capillary Electrophoresis. Chinese Journal of Analytical Chemistry, 2008, 36(12), 1646-50.
[13].Y. Pang#, *, S. Sutoko#, Y. Horimoto, D. Weng, K. Montagne, K. Komori, K. Takano, R. Shirakashi, M. Anzai, T. Niino, Y. Sakai. Biodegradable and hollowed micro-scaffolds for improved modular assembly-based tissue engineering: design, 3D fabrication, and feasibility in randomly packed perfusion culture. Biochemical Engineering Journal, in revision; (# Equal contribution)
[14].TK. Liu, Y. Pang*, R. Yao, W. Sun*. An integrated cell printing system for the construction of heterogeneous tissue models, Acta Biomaterialia, in revision;
[15].TK. Liu, R. Yao, Y. Pang, W. Sun*. Review on Biofabrication and Applications of Heterogeneous Tumor Models. Journal of Tissue Engineering and Regenerative Medicine, in revision.
[16].Y. Li, T. Zhang*, Y. Pang, L. Li, ZN. Chen, W. Sun*. 3D bioprinting of hepatoma cells and application with microfluidics for pharmacodynamic test of Metuzumab. Biofabrication, in revision.
论著
[1]. 酒井康行, 厖媛, ステファニー・ウタミ・ストコ, 新野俊樹. "再生医療・創薬のための3次元細胞培養技術". 階層的流路ネットワークを配備した組織再構築用担体, 紀ノ岡正博監修, シーエムシー出版, 第10章, 印刷中。