研究领域:生物制造与组织工程、生物3D打印、生命系统工程
主要研究方向:
围绕复杂生命组织/器官及生物器件构建中的关键科学和技术问题,研究生物制造及生物微环境构建的基本理论,开发多细胞异质复杂结构类组织体外构建及功能重建的关键核心技术,并用于体内病损组织修复、体外病理/药理/生理学模型、环境与药毒性检测、细胞机器人、生命系统工程等领域的应用基础研究。
主要研究兴趣聚焦在:
(1)多细胞异质复杂结构的生物/细胞3D打印原创性关键技术
(2)血管化类组织构建的关键技术,及在组织工程、药物检测领域的应用
(3)心肌、神经(脑)、骨软骨、肌肉等组织再生与体外微生理系统制造
(4)响应性、导电性等智能水凝胶材料研发与3D打印技术集成
(5)模拟复杂生物微环境的组织/器官芯片、生物反应器及在线检测技术
(6)细胞机器人与生物机器装置制造技术与理论
是生物制造与快速成形北京市重点实验室、生物三维打印北京市国际科技合作基地以及“生物制造及体外生命系统工程”交叉学科创新引智基地(111基地)骨干成员。主持或参与国家级、省部级课题十余项,在Biofabircation,Journal of Tissue Engineering and Regenerative Medicine等国际期刊发表学术论文和领域内核心会议论文40余篇,国际会议邀请报告6次,授权专利17项(含1项国际专利),参与编写书籍1本。指导博士后、博士生、硕士生十余名,学生曾获清华大学优秀硕士学位论文、北京市普通高等学校优秀毕业生等荣誉。
学术兼职:
2017.12-至今:英国皇家物理学会IOP旗下杂志Biomedical Physics and Engineering Express编委(Editorial Board)
2017.04-至今:中国机械工程学会生物制造工程分会总干事;
2015.05-至今:中国生物材料学会生物材料先进制造分会秘书长;
主要承担的科研项目:
人类心肌微组织芯片的3D打印构建及在药物检测中的应用研究,国家自然科学基金面上项目,2018-2021,项目负责人。
基于MRI三维有限元模型的个体化3D组织工程补片的构建,国家自然科学基金面上项目,2016-2019,项目骨干,单位负责人。
基于3D打印技术的类脑组织芯片构建研究,国防科技创新特区项目,2017-2018,项目负责人。
基于三维打印技术的细胞机器人构建基础研究,清华大学自主科研计划青年教师基础研究专项,2015-2017,项目负责人。
基于3D打印和微流体技术的新型三维体外肿瘤共培养模型芯片的研究,国家自然科学基金委与韩国国家研究基金会合作交流项目,2014-2016,项目负责人。
仿生结构组织工程心肌的构建及其体外复合式培养技术研究,国家自然科学基金青年项目,2013-2015,项目负责人。
组织工程心肌的力-电耦合复合式培养训练研究,中国博士后科学基金项目,2010-2011,项目负责人。
空间微生理系统的3D 打印构建及应用,空间科学战略性先导科技专项预研项目,2018-2019,项目骨干。
建立基于iPS 细胞及细胞3D 打印模型药物筛选系统及成药性评价技术,国家科技重大专项重大新药创制项目,2015-2018,项目骨干。
基于细胞精确受控组装体外仿生模型构建的基础研究,国家自然科学基金重点项目, 2013-2017,项目骨干。
异质细胞集成三维打印装备的开发及体外三维异质肿瘤模型的构建研究,北京市增材制造(3D打印)科技创新与产业培育专项,2014-2017,项目骨干。
复杂组织器官构建关键技术及产品研发,国家高技术研究发展计划(863计划)课题,2012-2015,项目骨干。
生物/纳米集成技术的发展前沿及展望,国家自然科学基金委科学部主任基金项目,2011,项目骨干。
代表性期刊论文:
[1] Yongcong Fang, Ting Zhang*, Lei Zhang, Wenfang Gong, Wei Sun. Biomimetic design and fabrication of scaffolds integrating oriented micro-pores with branched channel networks for myocardial tissue engineering. Biofabrication, 2019. (Accepted)
[2] Shuaijun Jia#, Jing Wang#, Ting Zhang#, Weimin Pan, Zhong Li, Xin He, Chongfei Yang, Qining Wu, Wei Sun, Zhuo Xiong, Dingjun Hao. Multilayered Scaffold with a Compact Interfacial Layer Enhances Osteochondral Defect Repair. ACS Applied Materials Interfaces, 2018, 10, 20296−20305.
[3] Ting Zhang*, Hefeng Zhang, Laquan Zhang, Shuaijun Jia, Jian Liu, Zhuo Xiong, Wei Sun. Biomimetic design and fabrication of multilayered osteochondral scaffolds by low-temperature deposition manufacturing and thermal-induced phase-separation techniques. Biofabrication, 2017, 9(2): p.025021.
[4] Shuaijun Jia#, Ting zhang#, Weimin Pan, Jian Liu, Zhuo Xiong, Wei Sun. In vivo Evaluation of a Novel Oriented Scaffold- BMSC Construct for Enhancing Full-thickness Articular Cartilage Repair in a Rabbit Model. Plos One. 2015, 10(12): e0145667.
[5] Ting Zhang, Le Jin, Yongcong Fang, Feng Lin, Wei Sun, Zhuo Xiong. Fabrication of Biomimetic Scaffolds with Oriented Porous Morphology for Cardiac Tissue Engineering. Journal of Biomaterials and Tissue Engineering. 2014, 4(12), 1030-1039.
[6] Yu Zhao, Rui Yao, Liliang Ouyang, Hongxu Ding, Ting Zhang, Kaitai Zhang, Shuju Cheng, Wei Sun. 3D printing of Hela cells for cervical tumor model in vitro. Biofabrication, 2014, 6(3).
[7] Ting Zhang, Keren C. Yan, Liliang Ouyang, and Wei Sun. Mechanical characterization of bioprinted in vitro soft tissue Model. Biofabrication, 2013, 5(4):045010.
[8] Ting Zhang, Leo Q. Wan, Zhuo Xiong, Anna Marsano, Robert Maidhof, Miri Park, Yongnian Yan and Gordana Vunjak-Novakovic. Channelled scaffolds for engineering myocardium with mechanical stimulation. Journal of Tissue Engineering and Regenerative Medicine. 2012, 6(9):748-756.
[9] Mingfeng Li, Ting Zhang, Wei Sun, and Zhuo Xiong. Fabrication and assembling of hydrogel fibers into 3D bunchy constructs for engineering cardiac tissue. Vienna, Austria: the 3rd TERMIS World Congress, 2012. Journal of Tissue Engineering and Regenerative Medicine, 2012, 6(1), 384.
[10] Ting Zhang, Yongnian Yan, Xiaohong Wang, Zhuo Xiong, Feng Lin, Rendong Wu, Renji Zhang. Three-dimensional gelatin and gelatin/hyaluronan hydrogel structures for traumatic brain injury. Journal of Bioactive and Compatible Polymers, 2007, 22:19-29.
会议邀请报告:
[1] Ting Zhang. Biomimetic design and fabrication of pre-vascularized myocardial tissue. The 5th International Conference on Additive Manufacturing and Bio-Manufacturing (ICAM-BM 2018), Beijing, China. 2018.10.31. (Keynote Speaker, Session Chair)
[2] Ting Zhang. Engineering of biomimetic complex tissue with hierarchical structure for in vivo and in vitro studies. Hangzhou International Conference on Biomaterials, Bio-Design and Manufacturing (BDMC2018), Hangzhou, China. 2018.8.27. (Keynote Speaker)
[3] Ting Zhang#, Wei Sun*. 3D bioprinting and application in tissue engineering. Workshop on Recent Advances in 3D Printing of Biomaterials, 2018 Society for Biomaterials Annual Meeting, Atlanta, USA. 2018-4-11. (Invited Talk)
[4] Ting Zhang#, Wei Sun*. Low-Temperature Deposition Manufacturing (3D Printing) of bone and osteochondral scaffolds with gradient structure for in vivo study. MRS/Kavli Future of Materials Workshop: 3D Printing of Biomedical Materials and Devices, 2017.12.02, Boston. (Invited Talk)
[5] Ting Zhang. Bio-3D printing techniques for the fabrication of vascularized myocardial tissue. International Conference on Biofabrication 2017, 2017.10.15-18, Beijing. (Invited Talk, Session Chair)
[6] Ting Zhang. Bio-3D printing - Design and Fabrication of Living Constructs with 3D Printing Techniques. Symposium on Personalized Intelligent Living: Human, Robot and Nature, 2017.06.28-30, Beijing. (Invited Talk)
授权专利:
已授权中国发明专利16项,国际专利1项。