Associate Professor

· Ph.D, Bioengineering, The University of Tokyo, Japan Oct. 2010-Sept. 2013

· Internship, Harvard Medical School, USA Jun. 2011-Aug. 2011

· M.S, Pharmaceutical Chemistry, Chongqing University, China Sept. 2007- July 2010

· B.S, Pharmaceutical Engineering, Chongqing University, China Sept. 2003- July 2007

· Associate Professor, Tsinghua University Dec. 2021-now

· Assistant Professor, Tsinghua University Dec. 2016-Nov. 2021

· Project Researcher (post-doctoral fellow), The University of Tokyo Oct. 2013-Nov. 2016

· Undergraduate courses:

00120232-90 Fundamentals of Engineering Biology

00120242-0 The Mystery of Mechanical Engineering-Experiment 17: Magical 3D Bio-Printing

· Graduate courses:

80120572-0 Principles and Methodologies of Biomanufacturing

80120612-0 Introduction to Computer-Aided Tissue Engineering

Yuan Pang is current an Associate Professor in the Department of Mechanical Engineering, Tsinghua University. Dr. Pang received Ph.D. degree in Bio-engineering from the University of Tokyo in 2013 and did her postdoc fellowship at the Institute of Industry and Science, University of Tokyo in 2013-2015. She started her work as an Assistant Professor at Bio-manufacturing center in Tsinghua University since 2016. Her research interests focus on developing new methods, technologies and explore new applications in the field of biomanufacturing and 3D bioprinting. She aims at in vitro construction of functional micro-organ/tissues, and further use them towards tissue repair, drug delivery and screening, pathology and inflammation study. She has published more than 30 high-impact SCI papers as the first and corresponding authors including Nature Review Immunology, Gut, International Journal of Extreme Manufacturing, Chemical Engineering Jounral, Nano Research, Advanced Healthcare Materials, Biofabrication in the last 5 years. During her research carrier, she got several scientific awards such as 2022 Science and Technology Nova of Beijing, 2020 Young Researcher Award by Lush Prize, Young Scientific Award of International Society of Biomaterials, publication awards of Tissue Engineering and Regenerative Medicine International Society- Asia Pacific. She now serves as the Board of Directors of The Asian Federation of the Societies for Alternatives in Animal Experiments (AFSAAE), committee member of Chinese Society of Toxicity Testing and Alternatives, and the committee member of Micro/Nano Manufacturing Branch of the Chinese Society of Mechanical Engineering. She is also the Bio-Design and Manufacturing Associate/Academic Editors, International Journal of Extreme Manufacturing Youth Editor, Biomedical Materials Executive Editorial Board.

Selected Publications

[1]. GY. Li, JY. He, JH. Shi, XY. Li, LL. Liu, XL. Ge, WH. Chen, M. Yin, J. Jia, JL. Wang, SC. Lu, Y. Sakai, W. Sun, HK. Deng*, Y. Pang*. Bioprinting Functional Hepatocyte Organoids Derived from Human Chemically Induced Pluripotent Stem Cells to Treat Liver Failure. Gut, https://doi.org/ 10.1136/gutjnl-2024-333885;

[2]. C. Zhou, CR. Liu, ZD. Liao, Y. Pang*, W. Sun*. AI for biofabrication. Biofabrication, 17(2025) 17 012004; DOI 10.1088/1758-5090/ad8966;

[3]. H. Sun, Y. Wang, MH. Sun, XD. Ke, CC. Li, B. Jin, MC. Pang, YN. Wang, SZ. Jiang, LW. Du, SD. Du, SX. Zhong, HT. Zhao, Y. Pang, YL. Sun, ZY. Yang, HY. Yang, YL. Mao. Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer. Journal of Advanced Research, https://doi.org/10.1016/j.jare.2024.09.011;

[4]. YT. He, J. Li, L. Zhang, X. Zhu, Q. Fu*, Y. Pang*, Q. Liao. Nano zero-valent iron functioned 3D printing graphene aerogel electrode for efficient solar-driven biocatalytic methane production. Renewable Energy, 224(2024) 120146; https://doi.org/10.1016/j.renene.2024.120146;

[5]. JY. Ji, CJ. Zhao, C. Hua, L. Lu, Y. Pang*, W. Sun. 3D printing cervical implant scaffolds incorporated with drug-loaded carboxylated chitosan microspheres for long-term anti-HPV protein delivery. ACS Biomaterials Science & Engineering, 2024, 10, 1544−1553; https://doi.org/10.1021/acsbiomaterials.3c01594;

[6]. ZZ. Zhou, YT. Guo, CR. Liu, Y. Pang*, W. Sun. Engineering vascularized organotypic tissues via module assembly. International Journal of Extreme Manufacturing, 2024 6 012006;

[7]. ZZ. Zhou, Y. Pang*, JJ. Ji, JY. He, TK. Liu, LL. Ouyang, W. Zhang, XL. Zhang, ZG. Zhang, KT. Zhang, W. Sun*. Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies. Nature Reviews Immunology, https://doi.org/10.1038/s41577-023-00896-4；

[8]. TK. Liu, C. Zhou, JJ. Ji, XL. Xu, ZY. Xing, M. Shinohara, Y. Sakai, TP. Sun, XB. Feng, Z. Yu, Y. Pang*, W. Sun*. Spheroid on-demand printing and drug screening of endothelialized hepatocellular carcinoma model at different stages. Biofabrication, 15 (2023) 044102;

[9]. ZZ. Zhou, JY. He, Y. Pang*, W. Sun*. Reconstruction of tumor microenvironment via in vitro three-dimensional models. Biofabrication, 15 (2023) 032002;

[10]. YT. He, J. Li, L. Zhang, X. Zhu, Y. Pang*, Q. Fu*, Q. Liao. 3D-printed GA/PPy aerogel biocathode enables efficient methane production in microbial electrosynthesis. Chemical Engineering Journal, Volume 459, 1 March 2023, 141523;

[11]. D. Liu, Rr. Guo, SS. Mao, YJ. Huang, B. Wang, J. Dong, Y. Xin, RY. Xie, JZ. Shou, W. Sun, Y. Pang*, Y. Lu*. 3D magnetic field guided sunflower-like nanocatalytic active swarm targeting patients-derived organoids. Nano research, https://doi.org/10.1007/s12274-022-4851-z;

[12]. JY. He, C. Zhou, XL. Xu, ZZ. Zhou, M. Danoy, M. Shinohara, WJ. Xiao, D. Zhu, XY. Zhao, XB. Feng, YL. Mao, W. Sun, Y. Sakai, HY. Yang*, Y. Pang*. Scalable Formation of Highly Viable and Functional Hepatocellular Carcinoma Spheroids in an Oxygen-Permeable Microwell Device for Anti-Tumor Drug Evaluation. Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202200863;

[13]. JY. Ji, CJ. Wang, Z. Xiong, Y. Pang*, W. Sun*. 3D-printed scaffold with halloysite nanotubes laden as a sequential drug delivery system regulates vascularized bone tissue healing. Materials Today Advances, 2022, 8(15), 100259, doi:10.1016/j.mtadv.2022.100259;

[14]. TK Liu#, C. Zhou#, YC. Shao, Z. Xiong, D. Weng*, Y. Pang*, W. Sun. Construction and application of in vitro alveolar models based on 3D printing technology. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers, Doi: 10.1016/j.cjmeam.2022.100025, (Back cover);

[15]. CJ. Zhao, JY. Ji, TJ. Y, J. Yang, Y. Pang*, W. Sun*. Affinity-controlled double-network hydrogel facilitates long-term release of anti-human papillomavirus protein. Biomedicines, 2021, 9(10), 1298; https://doi.org/10.3390/biomedicines9101298;

[16]. TK. Liu, YC. Shao, ZT. Wang, YQ. Chen, Y. Pang*, D. Weng*, W. Sun*. 3D printing in vitro hydrogel microcarriers by alternating viscous-inertial force jetting. Journal of Visualized Experiments, (170), e62252, https://doi: 10.3791/62252;

[17]. YT. He, Q. Fu, Y. Pang*, Q. Li, J. Li, X. Zhu, RH. Lu, W. Sun, Q. Liao, U. Schröder. Customizable design strategies for high-performance bioanodes in bioelectrochemical systems. iScience 24, 102163, March 19, 2021. https://doi.org/10.1016/j.isci.2021.102163;

[18]. K. Changsorn^#, Y. Pang^#, *,H. Matsumoto, HF. Hong, P. Wüthrich, W. Sun, Y. Sakai. 3D perfusion culture of mouse insulinoma in macro-porous scaffolds enhanced insulin production response. The International Journal of Artificial Organs, 2022 Jan;45(1):96-102. http://dx.doi.org/10.1177/0391398820985515;

[19]. XL. Xu, X. Qian, CC. Cao, Y. Pang, H. Zhou, LZ. Zhu, Z. Wang, MQ. Pang, DF. Wu, WH. Yu, FY. Kong, DL. Shi, YT. Guo, XX. Su, W. Hu, J. Yan, XB. Feng, HN. Fan. Advances in the pharmacological treatment of hepatic alveolar echinococcosis: From laboratory to clinic. Frontiers in microbiology, doi: 10.3389/fmicb.2022.953846; PUBLISHED 08 August 2022;

[20]. JY. He, JL. Wang, Y. Pang, H. Y, XQ. Qin, K. Su, T. Xu, HZ. Ren. Bioprinting of a hepatic tissue model using human-induced pluripotent stem cell-derived hepatocytes for drug-induced hepatotoxicity evaluation. International journal of bioprinting, 2022, 8(3): 176-190;

[21]. RH. Lu, WH. Zhang, YT. He, SY. Zhang, Q. Fu, Y. Pang*, W. Sun*. Ferric ion crosslinking-based 3D printing of a graphene oxide hydrogel and its evaluation as a bio-scaffold in tissue engineering. Biotechnology and Bioengineering, 2021, 118(2): 1006-1012, http://dx.doi.org/10.1002/bit.27592. (Inside Cover Image);

[22]. FH. Xie, LJ Sun, Y. Pang, G. Xu, B. Jin, HF. Xu, X. Lu, YY. Xu, SD. Du, YN. Wang, S. Feng, XT. Sang, SX. Zhong, X. Wang, W. Sun, HT. Zhao, HB. Zhang, HY. Yang*, PY. Huang*, YL. Mao*. Three-dimensional bio-printing of primary human hepatocellular carcinoma for personalized medicine. Biomaterials, 2021, 265, 120416;

[23]. JY. He#, Y. Pang#, *, HY. Yang, K. Montagne, M. Shinohara, YL. Mao, W. Sun, Y. Sakai. Modular assembly–based approach of loosely packing co-cultured hepatic tissue elements with endothelialization for liver tissue engineering. Annals of Translational Medicine, 2020 8(21): 1400. http://dx.doi.org/10.21037/atm-20-1598；

[24]. HY. Yang^#, LJ. Sun^#, Y. Pang^#, DD. Hu^#, HF. Xu, SS. Mao, WB. Peng, YN. Wang, YY. Xu, YC. Zheng, SD. Du, HT. Zhao, TY. Chi, X. Lu, XT. Sang, SX. Zhong, X. Wang, HB. Zhang, PY. Huang*, W. Sun*, YL. Mao*. Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure. GUT, http://dx.doi.org/10.1136/gutjnl-2019-319960. (# Equal contribution)

[25]. SS. Mao, Y. Pang*, TK. Liu, YC. Shao, JY. He, HY. Yang, YL. Mao, W. Sun*. Bioprinting of In Vitro Tumor Models for Personalized Cancer Treatment : A Review. Biofabrication, 12 (2020) 042001; https://dx.doi.org/10.1088/1758-5090/ab97c0;

[26]. SS. Mao, JY. He, Y. Zhao, TK. Liu, FH. Xie, HY. Yang, YL. Mao, Y. Pang*, W. Sun*. Bioprinting of patient-derived in vitro intrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing. Biofabrication, 12 (2020) 045014;

[27]. CJ. Zhao, ZT. Wang, C. Hua, JY. J, ZZ. Zhou, YC. Fang, D. Weng, L. Lu, Y. Pang*, W. Sun*. Design, Modeling and 3D Printing of Personalized Cervix Tissue Implant with Protein Release Function. Biomedical materials, 15 (2020) 045005, https://doi.org/10.1088/1748-605X/ab7b3b;

[28]. JY. Ji#, Y. Pang#, *, S. Sutoko, Y. Horimoto, W. Sun, T. Niino, Y. Sakai. Design, fabrication, and evaluation of polyglycolic acid modules with canals as tissue elements in cellular-assembly technology. Applied Science, 2020, 10(11), 3748; https://doi.org/10.3390/app10113748;

[29]. Y. Pang*, S. Sutoko, ZT. Wang, Y. Horimoto, K. Montagne, I. Horiguchi, M. Shinohara, D. Mathiue, T. Niino, Y. Sakai. Organization of liver organoids using Raschig ring-like micro-scaffolds and triple co-culture: Toward modular assembly-based scalable liver tissue engineering. Medical Engineering and physics, 76 (2020) 69–78. DOI: 10.1016/j.medengphy.2019.10.010;

[30]. SS. Mao, TK. Liu, HF. Hong, W. Sun, Y. Sakai, Y. Pang*. 3D fabrication of PCL micro-scaffolds with interconnected flow-channel and perfusion culture for in vitro construction of functional islet tissue. Proceedings - International Conference on Artificial Intelligence and Electromechanical Automation, AIEA 2020，DOI: 10.1109/AIEA51086.2020.00146;

[31]. LJ. Sun, HY. Yang, YN. Wang, XY. Zhang, B. Jin, FH. Xie, YK. Jin, Y. Pang, HT. Zhao, X. Lin, XT. Sang, HB. Zhang, F. Lin, W. Sun, PY. Huang, YL. Mao. Application of a 3D Bioprinted Hepatocellular Carcinoma Cell Model in Antitumor Drug Research. Frontiers in Oncology, 10:878. doi: 10.3389/fonc.2020.00878;

[32]. TK. Liu, Y. Pang*, ZZ. Zhou, R. Yao, W. Sun*. An integrated cell printing system for the construction of heterogeneous tissue models, Acta Biomaterialia, 2019, 95: 245-257;

[33]. Y. Pang^#, *, S. Sutoko^#, Y. Horimoto, D. Weng, K. Montagne, K. Komori, K. Takano, R. Shirakashi, M. Anzai, T. Niino, Y. Sakai. Biodegradable and hollowed micro-scaffolds for improved modular assembly-based tissue engineering: design, 3D fabrication, and feasibility in randomly packed perfusion culture. Biochemical Engineering Journal, 2019, 149 (15), 107239. (# Equal contribution);

[34]. TK. Liu, R. Yao, Y. Pang, W. Sun*. Review on Biofabrication and Applications of Heterogeneous Tumor Models. Journal of Tissue Engineering and Regenerative Medicine, 2019: 1-20. DOI: 10.1002/term.2949;

[35]. Y. Li, T. Zhang*, Y. Pang, L. Li, ZN. Chen, W. Sun*. 3D bioprinting of hepatoma cells and application with microfluidics for pharmacodynamic test of Metuzumab. Biofabrication, 2019, 11, 034102;

[36]. T. Zhang, F. Lin, T. Xu, L. Zhang, R. Yao, Y. Pang, SL. Mi, SH. Ma, W. Sun*. Bio-Manufacturing Research Center at Tsinghua University. Bio-Design and Manufacturing, 2019, 2, 137–143;

[37]. Y. Pang, SS. Mao, R. Yao, JY. He, ZZ. Zhou, L. Feng, KT. Zhang, SJ. Cheng and W. Sun*. TGF-β induced Epithelial-mesenchymal Transition in advanced cervical tumor model by 3D printing. Biofabrication, 10 (2018) 044102;

[38]. Y. Pang, F. Yang, Q. Gou, Z. Xia*. Rapid evaluation of antioxidants using a self-assembled capillary electrophoresis-chemiluminescence system. Basic & Clinical Pharmacology & Toxicology, 2017, 121 (Suppl. 5), 38-39;

[39]. Y. Pang, F. Yang, Q. Gou, Z. Xia*. Screening and evaluation of plasma protein binding effects to antioxidants in Herbal Ephedrae by capillary electrophoresis with chemiluminescence detection. Basic & Clinical Pharmacology & Toxicology, 2016, 119 (Suppl. 2), 35;

[40]. Y. Pang*, Y. Horimoto, S. Sutoko, K. Montagne, M. Shinohara, D. Mathiue, K. Komori, M. Anzai, T. Niino, Y. Sakai. Novel integrative methodology for engineering large liver tissue equivalents based on three-dimensional scaffold fabrication and cellular aggregate assembly. Biofabrication, 8 (2016) 035016;

[41]. Y. Pang, Y. Huang, F. Li, F. Yang, Z. Xia*. Rapid screening and evaluation of antioxidants in alkaloidal natural products by capillary electrophoresis with chemiluminescence detection. Analytical Methods, 2016, 8, 6545 - 6553;

[42]. Y. Pang*, S. Sutoko, Y. Horimoto, M. Anzai, T. Niino, Y. Sakai. Microfabrication and perfusion culture of new tissue Elements Possessing Hollow Structures with High Mechanical Strength towards Scaling-up to Implantable Liver. Tissue Engineering Part A, 2015, 21(S1), S3-S4;

[43]. Y. Pang*, S. Sutoko, Y. Horimoto, M. Anzai, T. Niino, Y. Sakai. An insight into in vitro construction of implantable liver: from “bottom up” integrated with “top down” aspects. Seisan Kenkyu, 2015, 67(3), 259-264;

[44]. T. Moro, Y. Itagaki, Y. Pang, I Horiguchi, Y. Sakai, T. Niino. Evaluation of scaffolds with plastic laser sintering of mixture of alkali-soluble filler. Seisan Kenkyu, 2015, 67(6), 617-623.

[45]. Y. Sakai*, Y. Pang, Y. Horimoto, M. Anzai, T. Niino. Tissue engineering scaffolds consisting of a macro-scale 3D flow channel network and small chambers. Bioindustry, 2014, 31(1), 45-50.

[46]. Y. Sakai*, Y. Pang, Y. Horimoto, M. Anzai, T. Niino. Design and organization of liver tissues based on oxygen supply. Journal of the heat transfer society of Japan, 2014, 53(222), 10-5.

[47]. Y. Pang*, K. Montagne, M. Shinohara, K. Komori, Y. Sakai. Liver tissue engineering based on aggregate assembly: efficient formation of endothelialized rat hepatocyte aggregates and their immobilization with biodegradable fibers. Biofabrication, 2012, 4(4), 045004. (Cover image);

[48]. Z. Xia*, Y. Pang, G. Zheng. Study on the Antioxidantive Biological Fingerprints of Astragalus Based on Capillary Electrophoresis. Chinese Journal of Analytical Chemistry, 2008, 36(12), 1646-50;

Book Chpater

[1]. Yuan Pang, Jingyuan Ji, Yasuyuki Sakai. “Design and organization of 3D tissues with branching/joining flow channel network based on oxygen transfer”. Chapter 10 Volume 1 “Emerging Technologies for Biofabrication and Biomanufacturing” in Emerging Technologies in Biophysical Sciences: A World Scientific Referenc, World Scientific Publishing Company press, 2022-05 published;

[2]. Yuan Pang, Wei Sun, Jingyuan Ji, Jianyu He. Chapter 4 “Application of 3D printing in toxicology” in “Toxicology in Vitro”, Peking University Medical Press, 2021.10;

[3]. 酒井康行, 厖媛, ステファニー・ウタミ・ストコ, 新野俊樹. "再生医療・創薬のための3次元細胞培養技術". 階層的流路ネットワークを配備した組織再構築用担体, 紀ノ岡正博監修, シーエムシー出版, 第10章, 2018。

Patent

[1]. Y. Pang, YT Guo. Cell culture device and its preparation, cultivation method. China ZL 202410954219.9；

[2]. Y. Pang, ZZ. Zhou, W. Sun, JY. He. A methodology of vascularized tissue construction based on 3D printing of cellular aggregates and its application. China ZL2019112559175;

[3]. Y. Pang, Q. Fu, YT. He, WH. Zhang, RH. Lu, Y. Tan. 3D printing of graphene oxide for three-dimensional microbial electrode with gradient pores and its preparation. China ZL 201811595184.5;

[4]. W. Sun, Y. Pang, ZZ. Zhou. A method of T lymphocyte amplification based on 3D printing. China 202010359007.8;

[5]. W. Sun, Y. Pang, JY. Ji, ZJ. Zhao, X. Yang. A methodology of construction of drug loaded artificial rectum. China ZL 202010289377.9;

[6]. W. Sun, R. Yao, Y. Pang. Preparation method and application of a cryogel scaffold. China ZL 2015105904596;

[7]. W. Sun, Y. Pang, R. Yao, X. Yang. Implantable cervix uterus and its preparation method. China ZL 201610284350.4.

[1]. 2023 Chinese Society of Mechanical Engineering Excellent Paper Award

[2]. 2023 International Journal of Extreme Manufacturing Outstanding Author Award;

[3]. 2022 Science and Technology Nova Plan of Beijing;

[4]. 2020 Young Researcher Prize by The Lush Prize，Construction of advanced in vitro tissue models based on 3D bioprinting and their application in drug discovery and toxicity test，2020.11;

[5]. BEST poster awarded by Unilever International Scientific Workshop on Non-animal Approaches for Chemical Safety, 2019.04;

[6]. BEST Young Scientist Paper Award by the 4th International Conference on Toxicity Testing Alternatives & Translational Toxicology/ the 2nd Asian Congress on Alternatives, 2018.10;

[7]. BEST poster awarded by Termis-AP conference, 2017.09;

[8]. Young Scientist Award and First prize for Excellent Paper by The 11th Chinese National Conference on

Regenerative Medicine, 2015.06.

[9]. Young Scientist Award by 9th World Biomaterials Congress, 2012.06.